Paradowska Katarzyna, Wolniak Michał, Fijałek Zbigniew, Wawer Iwona
Department of Physical Chemistry, Medical University of Warsaw, Warsaw, Poland.
Acta Pol Pharm. 2008 May-Jun;65(3):295-301.
Cross-polarization (CP) magic angle spinning (MAS) 13C NMR spectroscopy has become a routine tool in pharmacy, employed to identify and characterize drugs in the solid phase. 13C CPMAS NMR spectra were recorded for solid hydrocortisone 21-hemisuccinate and suxamethonium chloride. White crystalline substances, such as these two drugs, can be easily distinguished; and solid-state 13NMR spectra of remarkably good quality are obtained in less than half an hour. 13C CPMAS chemical shifts for solid suxamethonium chloride and hydrocortisone sodium hemisuccinate are given, as well as cross-polarization kinetic parameters for suxamethonium chloride.
