Byrn S R, Gray G, Pfeiffer R R, Frye J
J Pharm Sci. 1985 May;74(5):565-8. doi: 10.1002/jps.2600740516.
The solid-state 13C-NMR spectra of the polymorphs of benoxaprofen, nabilone, and cefazolin are reported using the cross-polarization/magic-angle spinning (CP/MAS) technique. In general, the spectra of the different crystal forms are different. In favorable cases the spectra of the drug in a pharmaceutical granulation can be discerned. These results provide a preliminary indication that solid-state NMR spectroscopy is a useful technique for the investigation of drug polymorphs and drugs in their dosage forms.
采用交叉极化/魔角旋转（CP/MAS）技术报道了贝诺洛芬、纳布啡和头孢唑林多晶型物的固态13C核磁共振谱。一般来说，不同晶型的谱图是不同的。在有利的情况下，可以辨别药物在药物颗粒中的谱图。这些结果初步表明，固态核磁共振光谱是研究药物多晶型物及其剂型中药物的一种有用技术。
