Roberts M S, D'Agostino R B, Dillon M, Odell P
New England Deaconess Hospital.
Int J Technol Assess Health Care. 1991;7(2):156-70. doi: 10.1017/s0266462300005055.
To assess the role of observational data bases in technology assessment, we examined 26 articles from the Framingham Heart Study that evaluated a technology, therapy, or predictive instrument. These assessments were grouped into four categories: (a) the study of a technology voluntarily in use by the cohort, (b) the application of an external technology to members of the cohort, (c) the use of the Framingham results to evaluate an unrelated assessment, and (d) the use of the results to validate predictive instruments from other studies. Factors that contribute to the ability of the study to assess voluntary and external technologies include long-term follow-up, a stable cohort, and storage of such nonnumeric data as cardiograms and blood samples. Framingham results have been used to determine outcome measures in later studies. Although the Framingham Study was not designed to assess a technology, we found that large-scale, observational data bases can and do contribute to technology assessment.
为评估观察性数据库在技术评估中的作用，我们查阅了弗雷明汉心脏研究的26篇文章，这些文章评估了一项技术、疗法或预测工具。这些评估分为四类：(a) 对队列中自愿使用的技术的研究；(b) 对队列成员应用外部技术；(c) 利用弗雷明汉研究结果评估不相关的评估；(d) 利用研究结果验证其他研究中的预测工具。有助于该研究评估自愿性技术和外部技术的因素包括长期随访、稳定的队列以及心电图和血样等非数字数据的存储。弗雷明汉研究结果已被用于确定后续研究的结果指标。尽管弗雷明汉研究并非旨在评估一项技术，但我们发现大规模观察性数据库能够且确实对技术评估有所贡献。
