Liao Ying, Liu Ying, Mi Jie, Tang Chaoshu, Du Junbao
Department of Pediatrics, Peking University First Hospital, Beijing 100034, People' Republic of China.
Acta Paediatr. 2008 Oct;97(10):1449-53. doi: 10.1111/j.1651-2227.2008.00946.x. Epub 2008 Jul 17.
Since the mortality rate due to cardiovascular disease continues to increase, research into dyslipidemia has been emphasized in not only adults but also paediatric populations. We aimed to study the risk factors of dyslipidemia in Chinese children.
Nine hundred and sixty-two children, aged 6-18 years, in Beijing were enrolled. For each child, data were collected on body height (cm), body weight (kg), sitting height (cm), waist circumference, upper arm circumference, serum lipid levels, as well as familial history of dyslipidemia and early onset cardiovascular disease. Subgroups were determined on the basis of age and sex.
The prevalence rate of dyslipidemia was 11.1% (107/962). Children with dyslipidemia differed significantly from those without, in sitting height, upper arm circumference, body mass index (BMI), waist-to-height ratio (WHR) and diastolic and systolic blood pressure (p < 0.05). Logistic regression analysis suggested that WHR, diastolic blood pressure and positive familial history were risk factors for dyslipidemia in children.
Sitting height, upper arm circumference, BMI, WHR, diastolic pressure and systolic pressure were significantly higher in dyslipidemic children than in normal subjects in China. BMI, WHR, diastolic pressure and familial history of dyslipidemia and early-onset cardiovascular disease were risk factors for dyslipidemia in Chinese children.
由于心血管疾病导致的死亡率持续上升,血脂异常的研究不仅在成年人中受到重视,在儿科人群中也备受关注。我们旨在研究中国儿童血脂异常的危险因素。
招募了962名年龄在6至18岁的北京儿童。收集每个儿童的身高(厘米)、体重(千克)、坐高(厘米)、腰围、上臂围、血脂水平,以及血脂异常家族史和早发性心血管疾病家族史。根据年龄和性别确定亚组。
血脂异常的患病率为11.1%(107/962)。血脂异常儿童与无血脂异常儿童在坐高、上臂围、体重指数(BMI)、腰高比(WHR)以及舒张压和收缩压方面存在显著差异(p < 0.05)。逻辑回归分析表明,WHR、舒张压和家族史阳性是儿童血脂异常的危险因素。
在中国,血脂异常儿童的坐高、上臂围、BMI、WHR、舒张压和收缩压显著高于正常儿童。BMI、WHR、舒张压以及血脂异常和早发性心血管疾病家族史是中国儿童血脂异常的危险因素。