Kim Young-Eun, Kim Do-Hoon, Roh Yong-Kyun, Ju Sang-Yhun, Yoon Yeo-Joon, Nam Ga-Eun, Nam Hyo-Yun, Choi Jun-Seok, Lee Jong-Eun, Sang Jung-Eun, Han Kyungdo, Park Yong-Gyu
Department of Family Medicine, Korea University, College of Medicine, Seoul, Republic of Korea.
Department of Family Medicine, Hallym University, College of Medicine, Chunchon, Republic of Korea.
PLoS One. 2016 Apr 12;11(4):e0153167. doi: 10.1371/journal.pone.0153167. eCollection 2016.
Ferritin is associated with various cardiometabolic risk factors such as dyslipidemia, hypertension, obesity, and insulin resistance in adults. We aimed to study the association between serum ferritin levels and dyslipidemia in adolescents, because dyslipidemia is considered an important modifiable cardiovascular risk factor in the young.
We analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009-2010 Korean National Health and Nutrition Examination Survey IV. Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender. Those in the highest quartile groups for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were diagnosed as having dyslipidemia. Those in the lowest quartile for high-density lipoprotein cholesterol (HDL-C) values were diagnosed with abnormal levels.
In boys, total cholesterol, LDL-C, and triglyceride concentrations were significantly correlated with serum ferritin levels. In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates. Furthermore, there was no significant correlation between serum ferritin levels and total cholesterol, LDL, and triglyceride concentrations in girls.
Serum ferritin levels were significantly associated with major dyslipidemia parameters, more prominently in boys than in girls, and this association represents a cardiometabolic risk factor.
铁蛋白与成人的各种心脏代谢危险因素相关，如血脂异常、高血压、肥胖和胰岛素抵抗。我们旨在研究青少年血清铁蛋白水平与血脂异常之间的关联，因为血脂异常被认为是年轻人中一个重要的可改变的心血管危险因素。
我们分析了2009 - 2010年韩国全国健康与营养检查调查IV中的1879名受试者（1026名男孩和853名女孩）。根据他们的血脂参数将受试者分为四分位数，这些参数根据年龄和性别进行分类。总胆固醇、低密度脂蛋白胆固醇（LDL-C）和甘油三酯浓度处于最高四分位数组的受试者被诊断为患有血脂异常。高密度脂蛋白胆固醇（HDL-C）值处于最低四分位数的受试者被诊断为水平异常。
在男孩中，总胆固醇、LDL-C和甘油三酯浓度与血清铁蛋白水平显著相关。在男孩和女孩中，即使在调整所有协变量后，血清铁蛋白水平与HDL-C值呈负相关。此外，女孩的血清铁蛋白水平与总胆固醇、LDL和甘油三酯浓度之间没有显著相关性。
血清铁蛋白水平与主要血脂异常参数显著相关，在男孩中比在女孩中更明显，这种关联代表了一种心脏代谢危险因素。
