Matsuda Takahisa, Saito Yutaka, Fu Kuang-I, Uraoka Toshio, Kobayashi Nozomu, Nakajima Takeshi, Ikehara Hisatomo, Mashimo Yumi, Shimoda Tadakazu, Murakami Yoshitaka, Parra-Blanco Adolfo, Fujimori Takahiro, Saito Daizo
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Am J Gastroenterol. 2008 Aug;103(8):1926-32. doi: 10.1111/j.1572-0241.2008.01931.x. Epub 2008 Jul 18.
Colonoscopy is considered the gold standard for the detection of colorectal polyps; however, polyps can be missed with conventional white light (WL) colonoscopy. The aim of this pilot study was to evaluate whether a newly developed autofluorescence imaging (AFI) system can detect more colorectal polyps than WL.
A modified back-to-back colonoscopy using AFI and WL was conducted for 167 patients in the right-sided colon including cecum, ascending and transverse colon by a single experienced colonoscopist. The patient was randomized to undergo the first colonoscopy with either AFI or WL (group A: AFI-WL, group B: WL-AFI). The time needed for both insertion and examination for withdrawal and all lesions detected in the right-sided colon were recorded.
Eighty-three patients were randomized to group A and 84 to group B. The total number of polyps detected by AFI and WL colonoscopy was 100 and 73, respectively. The miss rate for all polyps with AFI (30%) was significantly less than that with WL (49%) (P= 0.01).
AFI detects more polyps in the right-sided colon compared to WL colonoscopy.
结肠镜检查被认为是检测结直肠息肉的金标准；然而，传统白光（WL）结肠镜检查可能会漏诊息肉。本前瞻性研究的目的是评估一种新开发的自体荧光成像（AFI）系统是否比白光结肠镜检查能检测出更多的结直肠息肉。
由一名经验丰富的结肠镜检查医师对167例患者的右侧结肠（包括盲肠、升结肠和横结肠）进行了使用AFI和WL的改良背对背结肠镜检查。患者被随机分为先接受AFI或WL结肠镜检查（A组：AFI-WL，B组：WL-AFI）。记录插入和退镜检查所需的时间以及在右侧结肠发现的所有病变。
83例患者被随机分为A组，84例被分为B组。AFI和WL结肠镜检查检测到的息肉总数分别为100个和73个。AFI对所有息肉的漏诊率（30%）显著低于WL（49%）（P=0.01）。
与WL结肠镜检查相比，AFI在右侧结肠中能检测到更多的息肉。
