Gallardo Juan M
Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Instituto Mexicano del Seguro Social, México, Distrito Federal.
Rev Med Inst Mex Seguro Soc. 2008 Jan-Feb;46(1):109-16.
Salivary hypofunction caused by salivary gland disease, medication, or radiation may predispose for secondary oral mucosal disease. In these patients the protective coating of saliva is reduced or absent, leaving the oral mucosa more vulnerable. Candidiasis, burning mouth syndrome, and white lesions of oral mucosa are increased in frequency. The aim of management is to prevent oral pathological changes. The management procedure may include proper oral hygiene, saliva-stimulating agents, or saliva substitutes, depending on the severity of the salivary dysfunction. Treatment includes antifungal therapy if fungal infection appears. In severely distressed patients, local or systemic corticosteroids may be indicated. Precautions like refraining from smoking and avoid agents with detergents. Some antiinflammatory agents could be help.
由唾液腺疾病、药物或放疗引起的唾液功能减退可能易引发继发性口腔黏膜疾病。在这些患者中,唾液的保护作用减弱或缺失,使口腔黏膜更易受损。念珠菌病、灼口综合征和口腔黏膜白色病变的发生率增加。治疗的目的是预防口腔病理变化。治疗措施可能包括保持适当的口腔卫生、使用唾液刺激剂或唾液替代品,具体取决于唾液功能障碍的严重程度。如果出现真菌感染则进行抗真菌治疗。对于症状严重的患者,可能需要使用局部或全身性皮质类固醇。应采取如戒烟以及避免接触含洗涤剂的物质等预防措施。一些抗炎药物可能会有帮助。