Jensen J L, Barkvoll P
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway.
Ann N Y Acad Sci. 1998 Apr 15;842:156-62. doi: 10.1111/j.1749-6632.1998.tb09643.x.
Salivary hypofunction caused by salivary gland disease, medication, or radiation may predispose for secondary oral mucosal diseases. In these patients the protective coating of saliva is reduced or absent, leaving the oral mucosa more vulnerable. Candidiasis, burning mouth syndrome, and white lesions of the oral mucosa are increased in frequency. The aim of management is to prevent oral pathological changes. The management procedure may include proper oral hygiene, saliva-stimulating agents, or saliva substitutes, depending on the severity of the salivary dysfunction. Treatment includes antifungal therapy if candidiasis is diagnosed. In severely distressed patients, local or systemic corticosteroids may be indicated. Precautions, like refraining from smoking and avoiding toothpastes containing sodium lauryl sulfate, should also be taken. In the future, agents combining antibacterial and antiinflammatory actions, like triclosan, may show promising effects in patients with oral mucosal diseases secondary to salivary hypofunction.
由唾液腺疾病、药物或辐射引起的唾液功能减退可能易引发继发性口腔黏膜疾病。在这些患者中，唾液的保护作用减弱或缺失，使口腔黏膜更易受损。念珠菌病、灼口综合征和口腔黏膜白色病变的发生率增加。治疗的目的是预防口腔病理变化。治疗措施可能包括适当的口腔卫生、唾液刺激剂或唾液替代品，具体取决于唾液功能障碍的严重程度。如果诊断为念珠菌病，治疗包括抗真菌治疗。对于症状严重的患者，可能需要局部或全身使用皮质类固醇。还应采取一些预防措施，如戒烟和避免使用含有月桂醇硫酸酯钠的牙膏。未来，像三氯生这种兼具抗菌和抗炎作用的药物，可能对唾液功能减退继发的口腔黏膜疾病患者显示出良好疗效。
