Sarosi Andrea, Gonda Xenia, Balogh Gabriella, Domotor Eszter, Szekely Anna, Hejjas Krisztina, Sasvari-Szekely Maria, Faludi Gabor
Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4., 1125 Budapest, Hungary.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1667-72. doi: 10.1016/j.pnpbp.2008.06.014. Epub 2008 Jul 3.
The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression.
71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance.
We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele.
Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.
我们研究的目的是调查STin2基因多态性与重度抑郁症认知功能障碍之间的关联。
对71例重度抑郁症患者和99例对照进行STin2基因分型。所有抑郁受试者和30例对照还完成了测量神经认知表现的测试。
我们发现，与对照组相比，抑郁症组中STin2.10/Stin2.10纯合基因型的频率显著更高。在抑郁症组中，至少有一个10重复等位基因拷贝的受试者与没有10重复等位基因的患者相比，在Stroop III测试中的干扰阈值降低。与至少有一个12重复等位基因拷贝的患者相比，没有12重复等位基因的抑郁症组在Rey听觉词语学习测试工作记忆和回忆任务中的平均表现明显较弱。
我们的结果表明，STin2.10的存在和STin2.12等位基因的缺失可能与在重度抑郁症中检测到的特征性认知功能障碍的一种可能的遗传内表型有关。
