血清素转运体基因的STin2多态性与重度抑郁症的神经认知内表型的关联。

Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder.

作者信息

Sarosi Andrea, Gonda Xenia, Balogh Gabriella, Domotor Eszter, Szekely Anna, Hejjas Krisztina, Sasvari-Szekely Maria, Faludi Gabor

机构信息

Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Kutvolgyi ut 4., 1125 Budapest, Hungary.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1667-72. doi: 10.1016/j.pnpbp.2008.06.014. Epub 2008 Jul 3.

DOI:10.1016/j.pnpbp.2008.06.014

PMID:18647635

Abstract

BACKGROUND

The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression.

METHODS

71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance.

RESULTS

We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele.

CONCLUSION

Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.

摘要

背景

我们研究的目的是调查STin2基因多态性与重度抑郁症认知功能障碍之间的关联。

方法

对71例重度抑郁症患者和99例对照进行STin2基因分型。所有抑郁受试者和30例对照还完成了测量神经认知表现的测试。

结果

我们发现，与对照组相比，抑郁症组中STin2.10/Stin2.10纯合基因型的频率显著更高。在抑郁症组中，至少有一个10重复等位基因拷贝的受试者与没有10重复等位基因的患者相比，在Stroop III测试中的干扰阈值降低。与至少有一个12重复等位基因拷贝的患者相比，没有12重复等位基因的抑郁症组在Rey听觉词语学习测试工作记忆和回忆任务中的平均表现明显较弱。