Hong H Q, Asahara T, Ito H, Watanabe H, Kimura A, Urushihara T, Marubayashi S, Fukuda Y, Nishiki M, Dohi K
Second Department of Surgery, Hiroshima University, School of Medicine, Japan.
Hiroshima J Med Sci. 1991 Mar;40(1):29-33.
The effect of portal arterialization was examined in 20 heterotopic auxiliary rat livers. Portal blood was supplied from recipient iliac artery (0.58 mm in diameter) connected to the donor portal vein using the cuff technique. Portal hypertension caused by arterial blood pressure resulted in the immediate operative death by bleeding in four of the rats (20%) from the spontaneous rupture of the graft capsule. Severe graft congestion was noticed at autopsy 3-14 days after transplantation in 13 rats. Massive portal and sinusoidal congestion and focal hemorrhagic necrosis were confirmed by pathological examination. The results of our study demonstrate that the portal arterialization used in the auxiliary rat liver transplantation would not be applicable unless the optimal hemodynamic condition is warranted.
在20个异位辅助大鼠肝脏中研究了门静脉动脉化的效果。门静脉血由受体髂动脉（直径0.58毫米）供应，采用袖套技术将其与供体门静脉相连。动脉血压引起的门静脉高压导致4只大鼠（20%）因移植肝包膜自发性破裂出血而在手术中立即死亡。13只大鼠在移植后3 - 14天尸检时发现严重的移植肝充血。病理检查证实有大量门静脉和窦状隙充血以及局灶性出血性坏死。我们的研究结果表明，除非保证最佳的血流动力学状况，否则辅助大鼠肝移植中使用的门静脉动脉化是不适用的。
