Matsui K, Fujioka Y, Kikuchi H, Yuge O, Fujii K, Morio M, Endo M
Department of Anesthesiology, Hiroshima University School of Medicine, Japan.
Hiroshima J Med Sci. 1991 Mar;40(1):9-13.
The effects of various volatile anesthetics on intramuscular Ca(2+)-related functions were studied with the skinned fiber technique in guinea pig skeletal muscles. All the volatile anesthetics tested significantly enhanced Ca(2+)-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) at clinical concentrations with negligible effects both on Ca2+ sensitivity of the contractile system and on Ca2+ uptake by the SR. A comparison was made of the enhancing effect of several volatile anesthetics on CICR at clinical concentrations. Halothane was the most potent, followed by methoxyflurane, isoflurane, enflurane, sevoflurane and diethyl ether. If CICR plays an important role in triggering MH, this order of volatile anesthetics on their enhancing effect on CICR, also corresponds to their potency in triggering MH.
采用豚鼠骨骼肌皮肤纤维技术，研究了各种挥发性麻醉剂对肌肉内钙相关功能的影响。所有受试挥发性麻醉剂在临床浓度下均显著增强了肌浆网（SR）的钙诱导钙释放（CICR），而对收缩系统的钙敏感性和SR对钙的摄取影响可忽略不计。比较了几种挥发性麻醉剂在临床浓度下对CICR的增强作用。氟烷作用最强，其次是甲氧氟烷、异氟烷、恩氟烷、七氟烷和乙醚。如果CICR在引发恶性高热（MH）中起重要作用，那么这种挥发性麻醉剂对CICR增强作用的顺序，也与它们引发MH的能力相对应。
