Nakajima T
First Department of Anesthesiology, School of Medicine, Toho University, Tokyo.
Masui. 1996 Nov;45(11):1347-53.
The effect of the number of carbon atoms of alcohols (1 mM) on intramuscular Ca(2+)-related functions was studied using the skinned fiber technique in guinea pig skeletal muscles. The rate of calcium induced calcium release (CICR) increased steadily with increasing number of carbon atoms until 6 and then fell. Ca2+ uptake by the sarcoplasmic reticulum (SR) was not affected with the number of carbon atoms of alcohols. Ca2+ sensitivity of the contractile system was affected with the number of carbon atoms of alcohols. The pCa-tension curves were shifted to the left at low concentrations of Ca2+, and decreased at high concentrations of Ca2+ (beyond carbon atoms 6). Alcohols enhanced CICR from the SR significantly, but the cut-off in potency was observed in higher numbers of carbon atoms as observed with volatile anesthetics. These results suggested that it is possible to use alcohols instead of halothane in caffeine-halothane-contracture test (CHCT).
利用豚鼠骨骼肌的皮肤纤维技术，研究了醇类（1 mM）碳原子数对肌肉内钙相关功能的影响。钙诱导钙释放（CICR）速率随着碳原子数增加而稳步上升，直至6个碳原子后下降。肌浆网（SR）对钙离子的摄取不受醇类碳原子数的影响。收缩系统的钙离子敏感性受醇类碳原子数的影响。在低钙离子浓度下，pCa-张力曲线向左移动，而在高钙离子浓度下（超过6个碳原子）则下降。醇类显著增强了SR的CICR，但与挥发性麻醉剂一样，在碳原子数较多时观察到效力的截止现象。这些结果表明，在咖啡因-氟烷挛缩试验（CHCT）中可以使用醇类替代氟烷。
