Cacciari E, Cicognani A, Pirazzoli P, Tassoni P, Zappulla F, salardi S, Bernardi F, Mazzanti L, Vianelli P
J Clin Endocrinol Metab. 1976 Nov;43(5):1146-52. doi: 10.1210/jcem-43-5-1146.
The pituitary reserve of GH, ACTH, TSH, LH, and FSH was determined in seven prepubertal birls suffering from congenital adrenal hyperplasia due to 21-hydroxylation defect and under treatment with cortisone acetate. GH and ACTH were studied during the insulin induced hypoglycemia test. The LH, FSH, and TSH reserved were assayed by means of the LH-RH and TRH tests. GH behavior proved to be similar to that found in normal subjects, whereas basal and/or after stimulus ACTH turned out to be higher than the upper limits of the normal range in five out of six girls. The mean basal value and the mean LH peak were not significantly higher than those found in normal prepubertal girls; the mean basal value and the mean FSH peak were lower than the mean of the control group. The difference is significant (P less than 0.05) only between the peak values. The mean basal TSH in the patients is significantly higher (P less than 0.01) than the mean value of the control group. The maximum TSH after TRH is not significantly different from the mean value fo the control group.
对7名患有因21-羟化缺陷所致先天性肾上腺皮质增生且正在接受醋酸可的松治疗的青春期前女孩，测定了其生长激素（GH）、促肾上腺皮质激素（ACTH）、促甲状腺激素（TSH）、促黄体生成素（LH）和促卵泡生成素（FSH）的垂体储备功能。在胰岛素诱发低血糖试验期间研究了GH和ACTH。通过促黄体生成素释放激素（LH-RH）试验和促甲状腺激素释放激素（TRH）试验测定了LH、FSH和TSH的储备功能。结果表明，GH的表现与正常受试者相似，而在6名女孩中，有5名女孩的基础ACTH和/或刺激后ACTH高于正常范围的上限。基础LH均值和LH峰值均值并不显著高于正常青春期前女孩；基础FSH均值和FSH峰值低于对照组均值。仅峰值之间差异有统计学意义（P<0.05）。患者的基础TSH均值显著高于（P<0.01）对照组均值。TRH刺激后的最大TSH与对照组均值无显著差异。
