Eskildsen P C, Jacobsen B B, Kastrup K W, Krabbe S, Lebech P E, Petersen K E
Acta Paediatr Scand Suppl. 1979;277:14-20. doi: 10.1111/j.1651-2227.1979.tb06185.x.
A total number of 23 patients treated with human growth hormone were retested by use of a combined pituitary stimulation test. Plasma concentrations of GH, FSH, LH, TSH, T4, T3, prolactin (PRL), ACTH and cortisol were measured before and after stimulation with hypoglycemia, TRH and LHRH. The test was performed in patients with persistent GH deficiency (group A) and patients with transitory GH deficiency (group B). In group A a normal pubertal development was found in three patients, whereas in prepubertal subjects the FSH/LH responses were smaller than those of prepubertal patients in group B. Also plasma ACTH increase was less pronounced in group A patients than in group B. In contrast, the plasma TSH and PRL responses were more sustained in group A than in group B. The secretory pattern of TSH and PRL was comparable in the two groups of patients. Thus, in patients with persistent GH deficiency additional multiple disturbances of the hypothalamic-pituitary function often appeared whereas in most patients with transitory GH deficiency the combined pituitary test was normal at the reinvestigation.
对23例接受人生长激素治疗的患者采用联合垂体刺激试验进行重新检测。在低血糖、促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LHRH）刺激前后，测定生长激素（GH）、促卵泡生成素（FSH）、促黄体生成素（LH）、促甲状腺激素（TSH）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）、催乳素（PRL）、促肾上腺皮质激素（ACTH）和皮质醇的血浆浓度。该试验在持续性生长激素缺乏患者（A组）和暂时性生长激素缺乏患者（B组）中进行。在A组中，3例患者青春期发育正常，而在青春期前受试者中，FSH/LH反应小于B组青春期前患者。此外，A组患者血浆ACTH的升高不如B组明显。相反，A组血浆TSH和PRL反应比B组更持久。两组患者TSH和PRL的分泌模式相当。因此，在持续性生长激素缺乏患者中，常出现下丘脑-垂体功能的额外多重紊乱，而在大多数暂时性生长激素缺乏患者中，重新检查时联合垂体试验正常。
