Blackman Samuel C, Evenson Amy R, Voss Stephan D, Barnewolt Carol E, Puder Mark
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Fetal Diagn Ther. 2008;24(2):119-25. doi: 10.1159/000142141. Epub 2008 Jul 17.
Neuroblastoma is the most common extracranial solid tumor of childhood, and the most common malignancy diagnosed during infancy. In comparison, neonatal neuroblastoma is relatively rare. Improvements in prenatal imaging and widespread use of fetal ultrasonography have led to an increased rate of prenatal diagnoses.
Case report and literature review.
We report a case of an intermediate-risk neuroblastoma, diagnosed at 36 weeks' gestation by ultrasound and subsequently visualized by fetal MRI, that resulted in spinal cord compression and decreased fetal movement. A multidisciplinary team approach resulted in rapid delivery, evaluation, biopsy, staging, and treatment implementation in a successful effort to preserve lower extremity function.
Prenatal diagnosis of neuroblastoma, management and outcomes are reviewed. Prompt diagnosis can strongly influence perinatal management and improve prognosis.
神经母细胞瘤是儿童最常见的颅外实体瘤，也是婴儿期最常见的恶性肿瘤。相比之下，新生儿神经母细胞瘤相对罕见。产前影像学的进步和胎儿超声的广泛应用导致产前诊断率有所提高。
病例报告及文献综述。
我们报告一例中度风险神经母细胞瘤病例，在孕36周时通过超声诊断，随后经胎儿磁共振成像（MRI）确认，该病例导致脊髓受压和胎动减少。多学科团队协作实现了快速分娩、评估、活检、分期及治疗实施，成功保住了下肢功能。
对神经母细胞瘤的产前诊断、管理及预后进行了综述。及时诊断可显著影响围产期管理并改善预后。
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