化疗作为先天性神经母细胞瘤合并截瘫的一种治疗选择。
Chemotherapy as a therapeutic option for congenital neuroblastoma complicated by paraplegia.
作者信息
Walter K N, Kratz C, Uhl M, Niemeyer C
机构信息
Department of Paediatrics, University Hospital Freiburg.
出版信息
Klin Padiatr. 2008 May-Jun;220(3):175-7. doi: 10.1055/s-2008-1065340.
BACKGROUND
Spinal compression can be a complication of neuroblastoma (NBL). Delayed or insufficient treatment of this condition may lead to permanent neurological sequelae. Therefore, appropriate treatment should be introduced promptly. Therapeutic options include neurosurgery, chemotherapy, and radiation therapy.
CASE REPORT
We report on a newborn male with congenital NBL who presented with complete paraplegia of the legs at birth. Tumor size diminished quickly and neurological symptoms partly recovered after the patient received chemotherapy consisting of vincristine, doxorubicine, and cyclophosphamide.
CONCLUSION
Rapid initiation of chemotherapy was safe and effective in a neonate with NBL complicated by spinal cord compression.
背景
脊髓受压可能是神经母细胞瘤（NBL）的一种并发症。对此病症治疗延迟或不充分可能导致永久性神经后遗症。因此，应及时采取适当治疗。治疗选择包括神经外科手术、化疗和放射治疗。
病例报告
我们报告一例患有先天性NBL的新生儿男性，出生时出现双腿完全性截瘫。在患者接受由长春新碱、阿霉素和环磷酰胺组成的化疗后，肿瘤大小迅速缩小，神经症状部分恢复。
结论
对于并发脊髓受压的NBL新生儿，迅速开始化疗是安全有效的。
Zotero 插件