药物治疗的时间节奏效应。
The temporal hormesis of drug therapies.
机构信息
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA.
出版信息
Dose Response. 2006 May 1;3(3):414-24. doi: 10.2203/dose-response.003.03.009.
Abstract
Recent publications in the field of asthma therapeutics and studies performed over the last decade in the treatment of chronic heart failure suggest a phenomenon called 'temporal hormesis'. This phenomenon can be defined as the beneficial action of drug after chronic administration as opposed to its detrimental acute effects. Temporal hormesis may be related to the classification of the drug molecule as an agonist, antagonist or an inverse agonist. This phenomenon may be a more general principal applicable in the treatment of other diseases apart from asthma and chronic heart failure.
摘要
最近在哮喘治疗领域的出版物和过去十年在慢性心力衰竭治疗方面进行的研究表明存在一种称为“时间激素”的现象。这种现象可以定义为药物在慢性给药后产生的有益作用，而不是其有害的急性作用。时间激素可能与药物分子被分类为激动剂、拮抗剂或反向激动剂有关。这种现象可能是一种更普遍的原则，除了哮喘和慢性心力衰竭之外，还可应用于其他疾病的治疗。
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