Carelli G, Iavicoli I
Istituto di Medicina del Lavoro, Università Cattolica del Sacro Cuore, Rome, Italy.
Hum Exp Toxicol. 2002 Feb;21(2):103-4; discussion 113-4. doi: 10.1191/0960327102ht219oa.
The authors comment on Calabrese and Baldwin's paper 'Defining Hormesis', which, to date, is the first attempt to provide a definition of hormesis that goes beyond the different interpretations of this phenomenon reported in the literature. While appreciating the effort made in this study to place hormesis in a general and at the same time specific context, the authors believe some clarifications are needed as regards the quantitative features of this phenomenon. In this connection, they speculate on whether Calabrese and Baldwin think it appropriate to include hormesis assessment criteria in the document, referring in particular to those reported in a previous paper. The authors share Calabrese and Baldwin's conclusion that future experimental models designed to study hormetic phenomena must necessarily include the time factor, which not only guarantees this phenomenon will be detected, but is also able to detect the specific type of hormesis.
作者们对卡拉布雷斯（Calabrese）和鲍德温（Baldwin）的论文《定义毒物兴奋效应》发表评论。迄今为止，该论文首次尝试给出毒物兴奋效应的定义，该定义超越了文献中对这一现象的不同解读。作者们赞赏该研究为将毒物兴奋效应置于一个普遍且同时具体的背景下所做的努力，但认为在这一现象的定量特征方面仍需一些澄清。就此，他们推测卡拉布雷斯和鲍德温是否认为在该文献中纳入毒物兴奋效应评估标准是合适的，尤其提及了之前一篇论文中所报道的标准。作者们认同卡拉布雷斯和鲍德温的结论，即未来旨在研究毒物兴奋效应现象的实验模型必须纳入时间因素，这不仅能确保检测到这一现象，还能检测到特定类型的毒物兴奋效应。
