糖皮质激素对神经元活力和存活的浓度依赖性作用。
Concentration dependent actions of glucocorticoids on neuronal viability and survival.
机构信息
Neurobiology Research Group, Hungarian Academy of Sciences at Eötvös Loránd University, Budapest, Hungary.
出版信息
Dose Response. 2006 Jun 20;4(1):38-54. doi: 10.2203/dose-response.004.01.004.Abraham.
Abstract
A growing body of evidence based on experimental data demonstrates that glucocorticoids (GCs) can play a potent role in the survival and death of neurons. However, these observations reflect paradoxical features of GCs, since these adrenal stress hormones are heavily involved in both neurodegenerative and neuroprotective processes. The actual level of GCs appears to have an essential impact in this bimodal action. In the present short review we aim to show the importance of concentration dependent action of GCs on neuronal cell viability and cell survival in the brain. Additionally, we will summarize the possible GC-induced cellular mechanisms at different GC concentrations providing a background for their effect on the fate of nerve cells in conditions that are a challenge to their survival.
摘要
越来越多的实验数据证据表明，糖皮质激素（GCs）在神经元的存活和死亡中可以发挥强大的作用。然而，这些观察结果反映了 GCs 的矛盾特征，因为这些肾上腺应激激素在神经退行性和神经保护过程中都有大量涉及。GC 的实际水平似乎对这种双模态作用有重要影响。在本次简短的综述中，我们旨在展示 GCs 浓度依赖性作用对脑内神经元细胞活力和细胞存活的重要性。此外，我们将总结不同 GCs 浓度下 GC 诱导的细胞机制，为它们在对神经细胞存活构成挑战的情况下对神经细胞命运的影响提供背景。
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