Martin M L, Jensen M D
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
J Clin Invest. 1991 Aug;88(2):609-13. doi: 10.1172/JCI115345.
To determine the contribution of the major body fat depots to systemic free fatty acid (FFA) availability, palmitate ([1-14C]-palmitate) release was measured from leg (lower body) and non-leg (upper body) fat in eight upper body obese (UB Ob), six lower body obese (LB Ob), and six nonobese (Non Ob) age-matched premenopausal women in the overnight postabsorptive state. Splanchnic palmitate release was determined in 16 of these subjects.
total palmitate release was greater in UB Ob (P less than 0.005) than LB Ob or Non Ob women (161 +/- 16 vs. 111 +/- 9 vs. 92 +/- 9 mumol/min, respectively). Despite increased leg fat mass in obese women, leg palmitate release was similar in each group. Therefore, leg fat palmitate release was greater in Non Ob women than LB Ob (P less than 0.01) or UB Ob (P = 0.06) women (3.7 +/- 0.3 vs. 2.4 +/- 0.2 vs. 2.7 +/- 0.2 mumol.kg fat-1.min-1, respectively). Upper body fat palmitate release was less (P less than 0.01) in LB Ob than Non Ob or UB Ob women (3.0 +/- 0.4 vs. 5.0 +/- 0.3 vs. 4.9 +/- 0.4 mumol.kg fat-1.min-1, respectively). Splanchnic palmitate release accounted for 20-32% of upper body fat palmitate release in each group (P = NS between groups). Leg fat palmitate release was significantly less than upper body fat palmitate release. We conclude that the major difference in resting FFA metabolism between UB Ob and LB Ob women is the ability of the later to down-regulate upper body fat lipolysis to maintain normal FFA availability.
为了确定主要体脂储存部位对全身游离脂肪酸（FFA）可用性的贡献，在隔夜吸收后状态下，测量了8名上半身肥胖（UB Ob）、6名下半身肥胖（LB Ob）和6名非肥胖（Non Ob）且年龄匹配的绝经前女性腿部（下半身）和非腿部（上半身）脂肪中棕榈酸（[1-14C]-棕榈酸）的释放量。在其中16名受试者中测定了内脏棕榈酸释放量。
UB Ob女性的总棕榈酸释放量（P<0.005）高于LB Ob或Non Ob女性（分别为161±16、111±9和92±9 μmol/min）。尽管肥胖女性的腿部脂肪量增加，但每组的腿部棕榈酸释放量相似。因此，Non Ob女性的腿部脂肪棕榈酸释放量高于LB Ob女性（P<0.01）或UB Ob女性（P = 0.06）（分别为3.7±0.3、2.4±0.2和2.7±0.2 μmol·kg脂肪-1·min-1）。LB Ob女性的上半身脂肪棕榈酸释放量低于Non Ob或UB Ob女性（P<0.01）（分别为3.0±0.4、5.0±0.3和4.9±0.4 μmol·kg脂肪-1·min-1）。每组内脏棕榈酸释放量占上半身脂肪棕榈酸释放量的20%-32%（组间P = 无显著性差异）。腿部脂肪棕榈酸释放量显著低于上半身脂肪棕榈酸释放量。我们得出结论，UB Ob和LB Ob女性在静息FFA代谢方面的主要差异在于，后者能够下调上半身脂肪的脂解作用以维持正常的FFA可用性。
