不同类型肥胖中前臂脂肪分解的调节。脂肪细胞异质性的体内证据。
Regulation of forearm lipolysis in different types of obesity. In vivo evidence for adipocyte heterogeneity.
作者信息
Jensen M D
机构信息
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
出版信息
J Clin Invest. 1991 Jan;87(1):187-93. doi: 10.1172/JCI114969.
UNLABELLED
Forearm and systemic adipose tissue free fatty acid (FFA) release was measured in eight nonobese, six lower-body obese, and eight upper-body obese women under basal, hyperinsulinemic, and hypoinsulinemic conditions to determine whether forearm fat is regulated in a similar manner as whole body fat.
RESULTS
Adipose tissue palmitate release was greater from forearm than whole body (5.97 +/- 0.75 vs. 3.84 +/- 0.34 mumol.kg fat-1.min-1, respectively, P less than 0.005, n = 22 subjects). Systemic palmitate release, relative to fat mass, was significantly (P less than 0.01) greater in nonobese than upper-body obese, and upper-body obese than lower-body obese women, and forearm adipose tissue palmitate release followed the same pattern. Hyperinsulinemia suppressed systemic and forearm lipolysis to similar degrees, however, hypoinsulinemia consistently increased systemic palmitate flux without increasing forearm palmitate release. These results confirm the heterogeneity of adipose tissue in an in vivo model and emphasize the need to consider which adipose tissue depots are responsible for the differences in systemic FFA flux in obese and nonobese humans.
未标注
在基础、高胰岛素血症和低胰岛素血症条件下，对8名非肥胖、6名下半身肥胖和8名上半身肥胖女性的前臂和全身脂肪组织游离脂肪酸（FFA）释放进行了测量，以确定前臂脂肪是否与全身脂肪以相似的方式受到调节。
结果
前臂脂肪组织中棕榈酸酯的释放量高于全身（分别为5.97±0.75与3.84±0.34μmol·kg脂肪⁻¹·min⁻¹，P<0.005，n = 22名受试者）。相对于脂肪量，非肥胖女性的全身棕榈酸酯释放量显著高于上半身肥胖女性，上半身肥胖女性又高于下半身肥胖女性（P<0.01），前臂脂肪组织中棕榈酸酯的释放也呈现相同模式。高胰岛素血症对全身和前臂脂肪分解的抑制程度相似，然而，低胰岛素血症持续增加全身棕榈酸酯通量，而不增加前臂棕榈酸酯释放。这些结果证实了体内模型中脂肪组织的异质性，并强调需要考虑哪些脂肪组织库导致了肥胖和非肥胖人群全身FFA通量的差异。
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