Wu Chi-Hong, Tian Geng-Shan, Wang Qin-Huan, Yu Yan-Yan, Dou Yong-Qing, Xu Xiao-Yuan
Department of Infectious Diseases, Peking University First Hospital, Beijing, China.
Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):516-9.
To study the clinical features and prognosis of hepatitis C virus (HCV)-related cirrhosis after the first occurrence of complications.
The clinical data of 89 decompensated HCV-related cirrhosis patients were analyzed. Univariate and multivariate analyses of the factors influencing the clinical decompensation were conducted.
Ascites was the most frequent first decompensation (44.9%), followed by upper gastrointestinal bleeding (23.6%), and self-originated peritonitis (20.2%), and hepatic encephalopathy (11.2%). During the follow-up of 62 months (60-66 months) ascites was the most frequent first decompensation (47. 2%), followed by self-originated peritonitis (18.0%), upper gastrointestinal bleeding (15.7%), and hepatic encephalopathy (7.9%). The 5-year survival rates after of the patients with hepatic encephalopathy, ascites, upper gastrointestinal bleeding and self-originated peritonitis as the first decompensated complications were 64.5%, 85.0%, 75.0%, and 83.3% respectively. Multivariate regression analysis showed that esophageal and gastro varices and bilirubin were independently correlated with survival.
Hepatitis C is a slowly progressing disease. Decompensation occurring in hepatitis C is significantly correlated with survival.
研究丙型肝炎病毒（HCV）相关性肝硬化首次出现并发症后的临床特征及预后。
分析89例失代偿期HCV相关性肝硬化患者的临床资料。对影响临床失代偿的因素进行单因素和多因素分析。
腹水是最常见的首次失代偿表现（44.9%），其次是上消化道出血（23.6%）、自发性腹膜炎（20.2%）和肝性脑病（11.2%）。在62个月（60 - 66个月）的随访期间，腹水仍是最常见的首次失代偿表现（47.2%），其次是自发性腹膜炎（18.0%）、上消化道出血（15.7%）和肝性脑病（7.9%）。以肝性脑病、腹水、上消化道出血和自发性腹膜炎作为首次失代偿并发症的患者，其5年生存率分别为64.5%、85.0%、75.0%和83.3%。多因素回归分析显示，食管胃静脉曲张和胆红素与生存率独立相关。
丙型肝炎是一种进展缓慢的疾病。丙型肝炎发生的失代偿与生存率显著相关。
