Hirano Yoji, Onitsuka Toshiaki, Kuroki Toshihide, Matsuki Yuji, Hirano Shogo, Maekawa Toshihiko, Kanba Shigenobu
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Psychiatry Res. 2008 Aug 30;163(3):260-9. doi: 10.1016/j.pscychresns.2007.07.002. Epub 2008 Jul 22.
The ability of the brain to suppress incoming irrelevant sensory input is termed 'sensory gating,' and auditory sensory gating is often indexed by the auditory evoked response. We recorded the auditory evoked magnetic fields to the human voice, using the conditioning-testing paradigm, to investigate whether or not healthy subjects show less activation to the second voice stimulus. Seventeen healthy adults (mean age 27.9+/-4.8 years, 9 males and 8 females) participated in the experiment. The auditory stimuli were presented monaurally as a series of 120 paired voices, with 500-ms interstimulus intervals and 6-s interpaired stimulus intervals. The P50m and the N100m responses were investigated, and dipole source localization was performed. Root mean squares of both P50m and N100m were significantly suppressed to the second stimulus bilaterally, and the suppression was more significant in N100m. The N100m was located significantly more laterally than the P50m for both hemispheres. These results therefore demonstrate the presence of sensory gating for auditory inputs of the human voice in the primary auditory cortex and the auditory association area.
大脑抑制传入的无关感觉输入的能力被称为“感觉门控”，而听觉感觉门控通常通过听觉诱发电位来衡量。我们采用条件-测试范式记录了对人类声音的听觉诱发磁场，以研究健康受试者对第二个声音刺激的激活是否减少。17名健康成年人（平均年龄27.9±4.8岁，9名男性和8名女性）参与了该实验。听觉刺激以单耳方式呈现，为一系列120对声音，刺激间隔为500毫秒，配对刺激间隔为6秒。研究了P50m和N100m反应，并进行了偶极子源定位。双侧对第二个刺激的P50m和N100m的均方根均被显著抑制，且N100m的抑制更为显著。两个半球的N100m均比P50m更偏向外侧。因此，这些结果证明了在初级听觉皮层和听觉联合区存在对人类声音听觉输入的感觉门控。
