Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Schizophr Res. 2010 Mar;117(1):61-7. doi: 10.1016/j.schres.2009.09.003. Epub 2009 Sep 23.
Patients with schizophrenia have auditory gating deficits; however, little is known about P50 auditory gating to human voices and its association with clinical symptoms. We examined the functioning of auditory gating and its relationship with the clinical symptoms in schizophrenia.
Auditory evoked magnetoencephalography responses to the first and the second voices stimuli were recorded in 22 schizophrenia patients and 28 normal control subjects. The auditory gating ratios of P50m and N100m were investigated and P50m-symptom correlations were also investigated.
Patients showed significantly higher P50m gating ratios to human voices specifically in the left hemisphere. Moreover, patients with higher left P50m gating ratios showed more severe auditory hallucinations, while patients with higher right P50m gating ratios showed more severe negative symptoms.
The present study suggests that schizophrenia patients have auditory gating deficits to human voices, specifically in the left hemisphere and auditory hallucinations of schizophrenia may be associated with sensory overload to human voices in the auditory cortex.
精神分裂症患者存在听觉门控缺陷；然而，对于人类声音的 P50 听觉门控及其与临床症状的关系知之甚少。我们研究了听觉门控的功能及其与精神分裂症临床症状的关系。
在 22 名精神分裂症患者和 28 名正常对照受试者中记录了对第一和第二声音刺激的听觉诱发脑磁图反应。研究了 P50m 和 N100m 的听觉门控比，并研究了 P50m-症状相关性。
患者表现出明显更高的 P50m 对人类声音的门控比，特别是在左半球。此外，左侧 P50m 门控比较高的患者出现更严重的幻听，而右侧 P50m 门控比较高的患者出现更严重的阴性症状。
本研究表明，精神分裂症患者对人类声音存在听觉门控缺陷，特别是在左半球，精神分裂症的幻听可能与听觉皮层对人类声音的感觉超负荷有关。
