台湾地区汉族系统性红斑狼疮患者白细胞介素-2外显子1区域的G/T多态性
G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan.
作者信息
Lin Ying-Ju, Wan Lei, Sheu Jim Jinn-Chyuan, Huang Chung-Ming, Lin Cheng-Wen, Lan Yu-Ching, Lai Chih-Ho, Hung Chien-Hui, Tsai Yuhsin, Tsai Chang-Hai, Lin Wei-Yong, Liu Hsin-Ping, Lin Ting-Hsu, Huang Yu-Min, Tsai Fuu-Jen
机构信息
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
出版信息
Clin Immunol. 2008 Oct;129(1):36-9. doi: 10.1016/j.clim.2008.05.011. Epub 2008 Jul 23.
Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91 x 10(-14); OR=3.94; 95% CI=2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE.
白细胞介素-2（IL-2）是T淋巴细胞激活所需的关键免疫调节细胞因子之一，在自身免疫性疾病中起重要作用。IL-2基因G/T多态性（rs2069763）与多发性硬化症和类风湿性关节炎有关。我们检验了一个假设，即这种多态性赋予系统性红斑狼疮（SLE）易感性。研究参与者为台湾的汉族SLE患者和健康对照组。我们的结果表明：（a）SLE患者中G等位基因频率显著更高（P = 1.91×10⁻¹⁴；OR = 3.94；95%CI = 2.74 - 5.66）；（b）抗核抗体（ANA）阳性的SLE患者中G等位基因频率显著更高（P = 0.033；OR = 4.21；95%CI = 1.01 - 17.51）；（c）盘状红斑的SLE患者中G等位基因频率显著更低（P = 0.019；OR = 0.41；95%CI = 0.19 - 0.88）。我们的结果表明，这种多态性可能参与了台湾SLE患者的遗传背景。
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