Zheng Tianyu, Xu Jianjiang
EYE and ENT Hospital of Fudan University, Shanghai, China.
Cornea. 2008 Aug;27(7):782-6. doi: 10.1097/ICO.0b013e31816f5ec3.
To show age-related changes in the presence of Vogt palisades in human limbus and the quantity and size of the limbal basal epithelial cells (LBECs) by in vivo confocal microscopy (CM).
One hundred sixty eyes of 160 healthy subjects were enrolled in this study after a routine slit-lamp examination. They were divided into 4 groups according to age: A (0-19 years), B (20-39 years), C (40-59 years), and D (>60 years). In vivo CM examination was performed on the inferior limbus, and the images were recorded. For each group, the positive rate of Vogt palisades was analyzed and the average size of LBECs was measured.
The positive rate of Vogt palisades in groups A, B, C, and D was 97.5% (39/40), 95.0% (38/40), 77.5% (31/40), and 40.0% (16/40), respectively, showing a significant decreasing tendency with age. The average size of LBECs in groups A, B, C, and D was 9.89 +/- 1.12, 10.65 +/- 1.45, 10.70 +/- 1.39, and 12.36 +/- 1.68 microm. Significant differences between groups were obvious except for that between groups B and C.
The presence of Vogt palisades in human limbus declined with age. Therefore, so did the qualities of LBECs, with an age-related cell size enlargement.
通过活体共聚焦显微镜（CM）观察人角膜缘Vogt栅栏的存在情况以及角膜缘基底上皮细胞（LBECs）的数量和大小随年龄的变化。
对160例健康受试者的160只眼进行常规裂隙灯检查后纳入本研究。根据年龄将其分为4组：A组（0 - 19岁）、B组（20 - 39岁）、C组（40 - 59岁）和D组（>60岁）。对下方角膜缘进行活体CM检查并记录图像。分析每组Vogt栅栏的阳性率并测量LBECs的平均大小。
A组、B组、C组和D组Vogt栅栏的阳性率分别为97.5%（39/40）、95.0%（38/40）、77.5%（31/40）和40.0%（16/40），随年龄呈显著下降趋势。A组、B组、C组和D组LBECs的平均大小分别为9.89±1.12、10.65±1.45、10.70±1.39和12.36±1.68μm。除B组和C组之间外，各组间差异明显。
人角膜缘Vogt栅栏的存在随年龄下降。因此，LBECs的质量也随年龄下降，且细胞大小随年龄增大。
