Richter Volker, Rassoul Fausi, Lüttge Florestin, Thiery Joachim
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Exp Clin Cardiol. 2007 Spring;12(1):51-3.
Population-based lipid screening studies were initiated in the city of Leipzig, Germany, and included more than 30,000 subjects. The objectives of the Lipid Study Leipzig (LSL) were to evaluate the cardiovascular risk factor profile and its dependence on age, nutrition and social factors. In addition, the study results were compared with those of other population-based studies, and the development of cardiovascular risk factors over a 10-year period was evaluated. LSL data were obtained from subjects recruited at community centres, work sites, schools and the University of Leipzig, Germany. Capillary blood cholesterol and high-density lipoprotein-cholesterol levels were measured using the Reflotron dry-chemistry system (Roche Diagnostics, Germany). Study data also included blood pressure, body mass index, waist-to-hip ratio, and the evaluation of dietary and lifestyle factors. The results of LSL show an age-dependent increase in cardiovascular risk, which may have been partly preventable. Furthermore, LSL showed an improvement in cardiovascular risk, with respect to plasma cholesterol, over the past 10 years in men and women older than 30 and 50 years, respectively. The known age dependence of total cholesterol and non-high-density lipoprotein-cholesterol is less pronounced for those following a healthy lifestyle and for vegetarians. This suggests that the age-dependent rise of these parameters is partly preventable.
德国莱比锡市开展了基于人群的血脂筛查研究，研究对象超过30000人。莱比锡血脂研究（LSL）的目的是评估心血管危险因素状况及其对年龄、营养和社会因素的依赖性。此外，还将该研究结果与其他基于人群的研究结果进行了比较，并评估了心血管危险因素在10年期间的发展情况。LSL数据来自在德国莱比锡社区中心、工作场所、学校和大学招募的研究对象。使用Reflotron干化学系统（德国罗氏诊断公司）测量毛细血管血胆固醇和高密度脂蛋白胆固醇水平。研究数据还包括血压、体重指数、腰臀比以及饮食和生活方式因素的评估。LSL结果显示心血管风险随年龄增长而增加，这在一定程度上可能是可以预防的。此外，LSL显示，在过去10年中，30岁以上男性和50岁以上女性的血浆胆固醇心血管风险有所改善。对于遵循健康生活方式的人和素食者来说，总胆固醇和非高密度脂蛋白胆固醇已知的年龄依赖性不太明显。这表明这些参数随年龄增长的上升在一定程度上是可以预防的。
