Sales C, Oliviero F, Spinella P
Servizio di Dietetica e Nutrizione Clinica, Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Via Giustiniani 2, Padua, Italy.
Reumatismo. 2008 Apr-Jun;60(2):95-101. doi: 10.4081/reumatismo.2008.95.
The beneficial effects of omega-3 polyunsaturated fatty acids have been widely described in the literature in particular those on cardiovascular system. In the last decade there has been an increased interest in the role of these nutrients in the reduction of articular inflammation as well as in the improvement of clinical symptoms in subjects affected by rheumatic diseases, in particular rheumatoid arthritis (RA). Nutritional supplementation with omega-3 may represent an additional therapy to the traditional pharmacological treatment due to the anti-inflammatory properties which characterize this class of lipids: production of alternative eicosanoids, reduction of inflammatory cytokines, reduction of T-lymphocytes activation, reduction of catabolic enzymes activity. The encouraging results of dietetic therapy based on omega-3 in RA are leading researchers to test their effectiveness on patients with other rheumatic conditions such as systemic lupus erythematosus and ankylosing spondylitis. Nutritional therapy based on food rich in omega-3 or on supplementation with fish oil capsules, proved to be a valid support to he treatment of chronic inflammatory rheumatic diseases.
ω-3多不饱和脂肪酸的有益作用在文献中已有广泛描述，尤其是对心血管系统的作用。在过去十年中，人们对这些营养素在减轻关节炎症以及改善受风湿性疾病影响的受试者（特别是类风湿性关节炎（RA））的临床症状方面的作用越来越感兴趣。由于这类脂质具有抗炎特性，用ω-3进行营养补充可能是传统药物治疗的一种补充疗法：产生替代类花生酸、减少炎性细胞因子、降低T淋巴细胞活化、降低分解代谢酶活性。基于ω-3的饮食疗法在RA中取得的令人鼓舞的结果，促使研究人员在患有其他风湿性疾病（如系统性红斑狼疮和强直性脊柱炎）的患者身上测试其有效性。基于富含ω-3的食物或鱼油胶囊补充剂的营养疗法，被证明是慢性炎性风湿性疾病治疗的有效支持。
