Bluestein Danny, Dumont Kris, De Beule Matthieu, Ricotta John, Impellizzeri Paul, Verhegghe Benedict, Verdonck Pascal
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
Comput Methods Biomech Biomed Engin. 2009 Feb;12(1):73-81. doi: 10.1080/10255840903077170.
Recent numerical studies of abdominal aortic aneurysm (AAA) suggest that intraluminal thrombus (ILT) may reduce the stress loading on the aneurysmal wall. Detailed fluid structure interaction (FSI) in the presence and absence of ILT may help predict AAA rupture risk better. Two patients, with varied AAA geometries and ILT structures, were studied and compared in detail. The patient specific 3D geometries were reconstructed from CT scans, and uncoupled FSI approach was applied. Complex flow trajectories within the AAA lumen indicated a viable mechanism for the formation and growth of the ILT. The resulting magnitude and location of the peak wall stresses was dependent on the shape of the AAA, and the ILT appeared to reduce wall stresses for both patients. Accordingly, the inclusion of ILT in stress analysis of AAA is of importance and would likely increase the accuracy of predicting AAA risk of rupture.
近期对腹主动脉瘤（AAA）的数值研究表明，腔内血栓（ILT）可能会减轻动脉瘤壁上的应力负荷。存在和不存在ILT情况下的详细流固耦合（FSI）可能有助于更好地预测AAA破裂风险。对两名具有不同AAA几何形状和ILT结构的患者进行了详细研究和比较。从CT扫描重建了患者特异性的三维几何形状，并应用了解耦FSI方法。AAA腔内复杂的流动轨迹表明了ILT形成和生长的一种可行机制。由此产生的峰值壁应力的大小和位置取决于AAA的形状，并且ILT似乎降低了两名患者的壁应力。因此，在AAA应力分析中纳入ILT很重要，并且可能会提高预测AAA破裂风险的准确性。
