Soković M, Glamoclija J, Cirić A, Kataranovski D, Marin P D, Vukojević J, Brkić D
Institute for Biological Research, S. Stankovic, Bulevar despota Stefana, Belgrade, Serbia.
Drug Dev Ind Pharm. 2008 Dec;34(12):1388-93. doi: 10.1080/03639040802130053.
The in vivo evaluation of the toxicological and antifungal activity of the essential oil of Thymus vulgaris L. and its main component thymol was made on 2-month-old male Wistar rats. We examined the therapeutic potency against experimentally induced dermatomycoses in rats, using the most frequent dermatomycetes, Trichophyton mentagrophytes, T. rubrum, and T. tonsurans. The therapeutic efficacy of a 1% solution of the essential oil of Thymus vulgaris and thymol as well as the commercial preparation bifonazole was evaluated. During the 37-day observation period the oil-treated animals were cured.
对2月龄雄性Wistar大鼠进行了百里香精油及其主要成分百里香酚的毒理学和抗真菌活性的体内评估。我们使用最常见的皮肤癣菌须癣毛癣菌、红色毛癣菌和断发毛癣菌，检测了其对大鼠实验性诱导皮肤真菌病的治疗效力。评估了1%百里香精油溶液、百里香酚以及市售制剂联苯苄唑的治疗效果。在37天的观察期内，用油治疗的动物痊愈。
