Brzezicki Grzegorz, Jankowski Roman, Blok Tomasz, Szymaś Janusz, Huber Juliusz, Szukała Agnieszka, Nowak Stanisław, Borejsza-Wysocki Maciej
Katedra i Klinika Neurochirurgii i Neurotraumatologii, Uniwersytet Medyczny im. Karola Marcinkowskiego, ul. Przybyszewskiego 49, 60-355 Poznań.
Neurol Neurochir Pol. 2008 May-Jun;42(3):223-30.
Scar formation after spine surgery in the lumbosacral region may be the cause of failed back surgery syndrome. Therefore efforts are made to find materials preventing excessive scar formation at the site of surgery. The aim of the study was to evaluate the usefulness of TachoComb application in prevention of epidural scar formation in a rat experimental model. This paper additionally presents a review of literature concerning other methods of local suppression of scar formation after posterior approaches to the lumbar spine.
The experimental study was carried out on 14 male Wistar rats. Rats were divided into 2 groups. Laminectomy was performed in the first group (control group: n=5). In the second group of animals (n=9) laminectomy was followed by TachoComb application on the exposed dura. Neurological condition of the studied animals was evaluated based on clinical observation, neurological tests and recording of somatosensory evoked potentials. Post mortem histological examination was the main method of assessment of the experimental material.
Presence of scar in the vertebral canal, its extent and severity differed between experimental groups. Electrophysiological results were also different between studied groups.
TachoComb prevents epidural scar formation after lumbar spine surgery. Its positive effect concerning neural transmission at the level of the medulla was proven by electrophysiological tests in which the amplitude of components I and II of SSEP in the TachoComb group were significantly higher than in the control group.
腰骶部脊柱手术后瘢痕形成可能是腰椎手术失败综合征的原因。因此，人们致力于寻找能防止手术部位过度瘢痕形成的材料。本研究的目的是评估速即纱在大鼠实验模型中预防硬膜外瘢痕形成的有效性。本文还对有关腰椎后路手术后局部抑制瘢痕形成的其他方法的文献进行了综述。
对14只雄性Wistar大鼠进行实验研究。大鼠分为2组。第一组（对照组：n = 5）行椎板切除术。第二组动物（n = 9）在椎板切除术后，将速即纱应用于暴露的硬脑膜上。基于临床观察、神经学测试和体感诱发电位记录，对研究动物的神经状况进行评估。死后组织学检查是评估实验材料的主要方法。
椎管内瘢痕的存在、范围和严重程度在实验组之间有所不同。研究组之间的电生理结果也不同。
速即纱可预防腰椎手术后硬膜外瘢痕形成。电生理测试证明了其在延髓水平对神经传导的积极作用，其中速即纱组体感诱发电位I和II成分的波幅显著高于对照组。
