Nef H M, Möllmann H, Hilpert P, Hamm C, Elsässer A
Kerckhoff-Klinik, Abteilung Kardiologie, Bad Nauheim.
Dtsch Med Wochenschr. 2008 Aug;133(31-32):1629-36; quiz 1637-40. doi: 10.1055/s-0028-1082779.
Tako-Tsubo cardiomyopathy (TTC) is a heart syndrome associated with transient contractile dysfunction. It is also referred to as "broken heart syndrome" or "transient left ventricular apical ballooning." Leading symptom is a sudden onset of chest pain, often accompanied by dyspnoea. Clinical features include new electrocardiographic changes (ST-Segment elevations, T wave inversions), moderate elevation of the cardiac enzymes and transient wall motion abnormalities in absence of significant coronary artery obstruction. Although causal treatment has not been established, TTC has a favourable prognosis with a low mortality and a complete recovery of the contractile function in nearly all cases. Although several mechanisms have been proposed, the pathophysiology is not yet fully understood. However, emotional and physical stress followed by excessive release of catecholamines might play a pivotal role in the development of TTC.
应激性心肌病（TTC）是一种与短暂收缩功能障碍相关的心脏综合征。它也被称为“心碎综合征”或“短暂性左心室心尖气球样变”。主要症状是突发胸痛，常伴有呼吸困难。临床特征包括新出现的心电图改变（ST段抬高、T波倒置）、心肌酶适度升高以及在无明显冠状动脉阻塞情况下的短暂室壁运动异常。尽管尚未确立病因治疗方法，但TTC预后良好，死亡率低，几乎所有病例的收缩功能均可完全恢复。虽然已经提出了几种机制，但病理生理学尚未完全阐明。然而，情绪和身体应激后儿茶酚胺过度释放可能在TTC的发生发展中起关键作用。
