Sadowski Marcin, Wozakowska-Kapłon Beata
Swietokrzyskie Cardiology Institute, Kielce, Poland.
Cardiol J. 2008;15(1):39-42.
Unequivocal data presenting the impact of different pacing modes on B-type natriuretic peptide levels has never been published. The aim of the study was to assess changes of plasma B-type natriuretic peptide (BNP) during permanent cardiac pacing in patients with sick sinus syndrome (SSS).
Patients with SSS undergoing routine pacemaker implantation were enrolled. Each subject underwent medical history and examination, echocardiography and blood sampling. Analysis was performed on 12 females (42.9%) and 16 males (57.1%), mean age 71.3 +/- 9.03 years, range 49-90 years. There were 11 pacemakers with AAIR pacing mode (39.3%; AAI group) and 17 with DDDR mode (60.7%; DDD group) implanted. There were no significant differences in age, concomitant diseases or echocardiographic parameters between the groups in baseline characteristics or plasma BNP levels (94.05 +/- 54.1 vs. 73.57 +/- 70.13 pg/mL; p > 0.2).
During six months follow-up no significant changes in plasma BNP levels in AAI group (94.05 +/- 54.1 vs. 94.05 +/- 54.1 pg/mL; p > 0.5) as well as in DDD group (73.57 +/- 70.1 vs. 82.39 +/- 58.9 pg/mL; p > 0.5) were noticed.
Atrial (AAIR) and dual chamber (DDDR) pacing did not influence plasma BNP levels in patients with SSS and preserved left ventricular systolic function.
尚未发表明确的数据来呈现不同起搏模式对B型利钠肽水平的影响。本研究的目的是评估病态窦房结综合征（SSS）患者永久性心脏起搏期间血浆B型利钠肽（BNP）的变化。
纳入接受常规起搏器植入的SSS患者。每位受试者均接受病史采集、体格检查、超声心动图检查及血液采样。分析了12名女性（42.9%）和16名男性（57.1%），平均年龄71.3±9.03岁，年龄范围49 - 90岁。植入了11台AAIR起搏模式的起搏器（39.3%；AAI组）和17台DDDR模式的起搏器（60.7%；DDD组）。两组在基线特征或血浆BNP水平方面，年龄、合并疾病或超声心动图参数均无显著差异（94.05±54.1 vs. 73.57±70.13 pg/mL；p>0.2）。
在六个月的随访期间，AAI组血浆BNP水平无显著变化（94.05±54.1 vs. 94.05±54.1 pg/mL；p>0.5），DDD组亦如此（73.57±70.1 vs. 82.39±58.9 pg/mL；p>0.5）。
心房（AAIR）起搏和双腔（DDDR）起搏对SSS且左心室收缩功能保留的患者的血浆BNP水平无影响。
