Cardiol J. 2007;14(3):266-73.
Clot formation is a crucial moment in the patophysiology of acute coronary syndromes. The aim of this research was to assess the relationship between immunoglobulin E (IgE), lipid parameters and chosen hemostatic markers. The role of IgE as a possible participant in the atherothrombotic process was also investigated.
A total of 80 patients with acute myocardial infarction (MI) was enrolled in the study. Concentrations of IgE, plasma lipid parameters, lipoprotein(a), markers of thrombin generation (TAT, AT III), markers of fibrinolysis (tPA:Ag, PAI-1:Ag, PAP, D-dimers) and markers of endothelial damage (von Willebrand factor) were measured in blood samples collected immediately after admission, before any treatment administration.
In patients with acute MI and with IgE concentration above 100 kU/l, IgE values were strongly, positively correlated with LDL concentration (p < 0.05), lipoprotein(a) concentration (p < 0.02) and negatively correlated with HDL plasma levels (p < 0.02). Exclusion of patients with IgE concentration lower than 150 kU/l strengthened the correlation between IgE concentration and LDL (p < 0.002) and lipoprotein(a) (p < 0.01) levels. It also revealed a significant correlation between IgE and TAT (p < 0.001), IgE and AT III (p < 0.002), and IgE and D-dimers (p < 0.05). IgE and TAT values measured 7, 14 and 40 days after infarction also showed significant positive correlation between increments of these parameters.
In patients with acute MI, a significant increase of thrombinogenesis and fibrinolysis markers is observed. Positive correlation between IgE concentration above 100 kU/l and markers of thrombinogenesis activation, lipid parameters and lipoprotein(a) levels, with significance increasing with IgE concentration and constant positive correlation between increments of IgE and TAT, can serve as evidence of IgE participation in the atherothrombotic process. (Cardiol J 2007; 14: 266-273).
血栓形成是急性冠状动脉综合征病理生理学中的一个关键时刻。本研究旨在评估免疫球蛋白 E（IgE）、脂质参数和选定的止血标志物之间的关系。还研究了 IgE 作为动脉血栓形成过程中可能的参与者的作用。
共纳入 80 例急性心肌梗死（MI）患者。在入院后立即采集血样，测量 IgE 浓度、血浆脂质参数、脂蛋白（a）、凝血酶生成标志物（TAT、AT III）、纤维蛋白溶解标志物（tPA：Ag、PAI-1：Ag、PAP、D-二聚体）和内皮损伤标志物（血管性血友病因子）。
在急性 MI 患者中，IgE 浓度超过 100 kU/l 的患者，IgE 值与 LDL 浓度（p < 0.05）、脂蛋白（a）浓度（p < 0.02）呈强烈正相关，与 HDL 血浆水平呈负相关（p < 0.02）。排除 IgE 浓度低于 150 kU/l 的患者后，IgE 浓度与 LDL（p < 0.002）和脂蛋白（a）（p < 0.01）水平之间的相关性增强。此外，IgE 与 TAT（p < 0.001）、IgE 与 AT III（p < 0.002）和 IgE 与 D-二聚体（p < 0.05）之间也存在显著相关性。梗死后第 7、14 和 40 天测量的 IgE 和 TAT 值也显示这些参数的增量之间存在显著的正相关。
在急性 MI 患者中，观察到血栓生成和纤维蛋白溶解标志物显著增加。IgE 浓度超过 100 kU/l 与凝血酶生成激活标志物、脂质参数和脂蛋白（a）水平之间的正相关，随着 IgE 浓度的增加而增加，IgE 和 TAT 增量之间存在恒定的正相关，可作为 IgE 参与动脉血栓形成过程的证据。（心血管杂志 2007；14：266-273）。
