Department of Preventive Medicine, Colleague of Medicine, Seoul National University, Seoul 08826, Korea.
Institute of Health and Environment, School of Public Health, Seoul National University, Seoul 08826, Korea.
Int J Environ Res Public Health. 2019 Nov 7;16(22):4350. doi: 10.3390/ijerph16224350.
Despite a potential link between immunoglobulin E (IgE) levels and cardiovascular disease, the effect of elevated total IgE levels on long-term mortality risk remains unclear. We prospectively investigated the association between total serum IgE levels and all-cause and cardiovascular mortality in US adults. We analyzed data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) and the NHANES (2005-2006) Linked Mortality Public File. The 2005-2006 NHANES data of 1496 older adults aged ≥50 years and who underwent a serum total IgE antibody test in the initial survey were included. After a median follow-up of 119 months, a significant association was observed between total serum IgE levels and cardiovascular mortality, with subjects with the highest total IgE exhibiting a 3.19-fold (HR = 3.19; 95% confidence interval: 1.71-5.96) increase in the risk of cardiovascular mortality compared with those with the lowest total IgE (≤16.80 kU/L). Furthermore, the mortality rate increased with an increase in total IgE levels, regardless of baseline history of cardiovascular diseases (e.g., myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease). This finding suggests that the elevation of IgE levels may be a risk factor for increased cardiovascular mortality.
尽管免疫球蛋白 E（IgE）水平与心血管疾病之间存在潜在联系，但升高的总 IgE 水平对长期死亡率风险的影响仍不清楚。我们前瞻性地研究了美国成年人总血清 IgE 水平与全因和心血管死亡率之间的关系。我们分析了来自 2005-2006 年全国健康和营养调查（NHANES）和 NHANES（2005-2006）关联死亡率公共文件的数据。纳入了在初始调查中接受血清总 IgE 抗体检测且年龄≥50 岁的 1496 名老年人的 2005-2006 年 NHANES 数据。中位随访 119 个月后，观察到总血清 IgE 水平与心血管死亡率之间存在显著关联，与总 IgE 水平最低（≤16.80 kU/L）的受试者相比，总 IgE 水平最高的受试者发生心血管死亡率的风险增加了 3.19 倍（HR = 3.19；95%置信区间：1.71-5.96）。此外，无论基线是否存在心血管疾病史（如心肌梗死、中风和无创诊断的大血管外周动脉疾病），总 IgE 水平的升高与死亡率的增加相关。这一发现表明 IgE 水平的升高可能是心血管死亡率增加的一个危险因素。
