Zou Gang-Ming
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21232, USA.
J Cell Physiol. 2008 Dec;217(3):598-604. doi: 10.1002/jcp.21541.
It has been suggested that cancer stem cells population within the solid tumor with indefinite proliferation potential drives the growth and metastasis of cancer. In literature, these malignant stem cells also named Cancer initiating cells. Cancer stem cells exhibit low rate of division and proliferation in their niche that help them to avoid chemotherapy and radiation. Epithelial cancers are believed to originate from transformation of tissue stem cells. Bone marrow-derived cells, which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy in the gastrointestinal tract. Pancreatic cancer is one of most common cause of cancer-related death. Pancreatic cancer stem cells have been characterized recently through serial transplantation of human pancreatic cancer cells. The phenotype of Pancreatic cancer stem cells has been defined as CD24(+)CD44(+)CD326 (ESA)(+). CD133 antigen has been also suggested as a potential marker for cancer stem cell in gastrointestinal tract but recently there is also debate in this regard. More recently, other cancer stem cells in gastrointestinal tract, such as colon cancer stem cells, liver cancer stem cells, have been also characterized in their phenotype. These advances clearly will bring the new strategy in cancer treatment and control in the gastrointestinal tract. In this review, the author will discuss the current status and progress about cancer stem cell research in gastrointestinal tract and liver.
有人提出，实体瘤中具有无限增殖潜能的癌症干细胞群体驱动着癌症的生长和转移。在文献中，这些恶性干细胞也被称为癌症起始细胞。癌症干细胞在其微环境中表现出低分裂和增殖率，这有助于它们避免化疗和放疗。上皮癌被认为起源于组织干细胞的转化。经常被招募到组织损伤和炎症部位的骨髓来源细胞，也可能是胃肠道恶性肿瘤的一个潜在来源。胰腺癌是癌症相关死亡的最常见原因之一。最近通过人胰腺癌细胞的连续移植对胰腺癌干细胞进行了表征。胰腺癌干细胞的表型已被定义为CD24(+)CD44(+)CD326 (ESA)(+)。CD133抗原也被认为是胃肠道癌症干细胞的一个潜在标志物，但最近在这方面也存在争议。最近，胃肠道中的其他癌症干细胞，如结肠癌干细胞、肝癌干细胞，也在其表型方面得到了表征。这些进展显然将为胃肠道癌症的治疗和控制带来新策略。在这篇综述中，作者将讨论胃肠道和肝脏癌症干细胞研究的现状和进展。
