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一例伴有强直及抗谷氨酸脱羧酶抗体阳性的进行性脑脊髓炎[校正后]

A case of progressive encephalomyelitis with rigidity and positive antiglutamic acid decarboxylase antibodies [corrected].

作者信息

Burn D J, Ball J, Lees A J, Behan P O, Morgan-Hughes J A

机构信息

Hammersmith Hospital, London, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1991 May;54(5):449-51. doi: 10.1136/jnnp.54.5.449.

DOI:10.1136/jnnp.54.5.449
PMID:1865210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC488547/
Abstract

A 50 year old woman developed progressive encephalomyelitis with rigidity over a three year period. Her CSF contained oligoclonal bands and both her serum and CSF contained antibodies directed against GABA-ergic synapses (antiglutamic acid decarboxylase [corrected] antibodies). These antibodies have recently been described in cases of stiff man syndrome. Both disorders may be part of a clinical spectrum that has an underlying autoimmune basis.

摘要

一名50岁女性在三年时间里出现了伴有僵硬的进行性脑脊髓炎。她的脑脊液中含有寡克隆带，其血清和脑脊液中均含有针对γ-氨基丁酸能突触的抗体（抗谷氨酸脱羧酶抗体）。最近在僵人综合征病例中描述了这些抗体。这两种疾病可能是具有潜在自身免疫基础的临床谱系的一部分。

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本文引用的文献

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A patient with reflex myoclonus and muscle rigidity: "jerking stiff-man syndrome".一名患有反射性肌阵挛和肌肉僵硬的患者：“抽动性僵人综合征”
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Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein.谷氨酸脱羧酶互补脱氧核糖核酸：编码一种具有酶活性融合蛋白的核苷酸序列。
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Stiff-man syndrome--an autoimmune disease?
N Engl J Med. 1988 Apr 21;318(16):1060-2. doi: 10.1056/NEJM198804213181610.
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Progressive encephalomyelitis with rigidity: a case report with magnetic resonance imaging findings.进行性脑脊髓炎伴僵硬：一例报告及磁共振成像结果
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Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.僵人综合征中针对γ-氨基丁酸能神经元和胰腺β细胞的自身抗体。
N Engl J Med. 1990 May 31;322(22):1555-60. doi: 10.1056/NEJM199005313222202.
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Progressive encephalomyelitis with rigidity.进行性脑脊髓炎伴强直
Brain. 1976 Mar;99(1):27-42. doi: 10.1093/brain/99.1.27.
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Spinal internuncial neurones in progressive encephalomyelitis with rigidity.进行性脑脊髓炎伴强直状态下的脊髓中间神经元
J Neurol Neurosurg Psychiatry. 1979 Sep;42(9):773-85. doi: 10.1136/jnnp.42.9.773.