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局部麻醉药诱发心脏骤停后成功但延长的复苏:可乐定是否有效?

Successful but prolonged resuscitation after local anesthetic-induced cardiac arrest: is clonidine effective?

作者信息

Braque S, Bernard-Bertrand F, Guillou N, Guezennec D, Canciani J P, Gentili M E

机构信息

Centre Hospitalier Privé Saint-Grégoire, 35760 Saint-Grégoire, France.

出版信息

Acta Anaesthesiol Belg. 2008;59(2):91-4.

PMID:18652106
Abstract

Local anesthetics when injected intravascularly result in serious cardiac complications including therapy-resistant cardiac arrest. We report a case of cardiac arrest after lumbar plexus block using a combination of 0.5% bupivacaine and 2% lidocaine with epinephrine (1:200.000). Resuscitation was performed by a combination of chest compression, repeated external countershocks and i.v.epinephrine. Clonidine had poor effect. The whole resuscitation required 90 minutes. The patient was discharged four days later without any sequelae. Blood sampling at 10 minutes showed a concentration of 2.02 mg/l lidocaine and 0.87 mg/l bupivacaine. Prolonged resuscitation is necessary in local anesthetic-induced cardiac arrest.

摘要

局部麻醉药血管内注射会导致严重的心脏并发症,包括难治性心脏骤停。我们报告一例在使用0.5%布比卡因和2%利多卡因加肾上腺素(1:200,000)联合进行腰丛阻滞术后发生心脏骤停的病例。通过胸外按压、反复体外除颤和静脉注射肾上腺素进行复苏。可乐定效果不佳。整个复苏过程需要90分钟。患者四天后出院,无任何后遗症。10分钟时采血显示利多卡因浓度为2.02mg/l,布比卡因浓度为0.87mg/l。对于局部麻醉药引起的心脏骤停,延长复苏时间是必要的。

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引用本文的文献

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Review and Outcome of Prolonged Cardiopulmonary Resuscitation.长时间心肺复苏的回顾与结果
Crit Care Res Pract. 2016;2016:7384649. doi: 10.1155/2016/7384649. Epub 2016 Jan 14.
2
Effective cardiopulmonary resuscitation - how long is not long enough?有效的心肺复苏——时长多久才算足够?
J Anaesthesiol Clin Pharmacol. 2011 Jan;27(1):125-7.
3
Cardiogenic shock associated with loco-regional anesthesia rescued with left ventricular assist device implantation.与局部区域麻醉相关的心源性休克通过植入左心室辅助装置得以救治。
J Cardiothorac Surg. 2010 Dec 8;5:126. doi: 10.1186/1749-8090-5-126.