Qiao Mingqi, Zhang Huiyun, Yu Yanhong, Ci Yuzhen, Xu Xujie, Ye Qing, Chen Yuzhen
College of Basic Medical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China.
J Tradit Chin Med. 2008 Jun;28(2):106-9. doi: 10.1016/s0254-6272(08)60026-6.
To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome (PMS) and reveal partial microcosmic mechanisms of adverse flow of liver-qi.
Estradiol (E2) and progesterone (P) levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.
In the group of PMS with adverse flow of liver-qi, the secretive peak value of E2 and P at the follicular phase significantly decreased, and the secretive peak value at the luteal phase did not come into being.
Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi. One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2 and P.
探讨卵巢激素变化对特定亚型经前期综合征（PMS）发病机制的影响，揭示肝郁气滞的部分微观机制。
采用放射免疫法测定月经周期不同阶段血清雌二醇（E2）和孕酮（P）水平。
肝郁气滞型PMS组中，E2和P在卵泡期的分泌峰值显著降低，黄体期未出现分泌峰值。
卵泡期E2和P分泌峰值低以及黄体期无分泌峰值是肝郁气滞型PMS的微观机制之一。特定亚型PMS的病理生理机制之一可能是E2和P持续处于低水平。
