肝郁气滞型经前期综合征患者血清雌二醇和孕酮水平的动态变化
Dynamic changes in serum estradiol and progesterone levels in patients of premenstrual syndrome with adverse flow of liver-qi.
作者信息
Qiao Mingqi, Zhang Huiyun, Yu Yanhong, Ci Yuzhen, Xu Xujie, Ye Qing, Chen Yuzhen
机构信息
College of Basic Medical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China.
出版信息
J Tradit Chin Med. 2008 Jun;28(2):106-9. doi: 10.1016/s0254-6272(08)60026-6.
OBJECTIVE
To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome (PMS) and reveal partial microcosmic mechanisms of adverse flow of liver-qi.
METHODS
Estradiol (E2) and progesterone (P) levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.
RESULTS
In the group of PMS with adverse flow of liver-qi, the secretive peak value of E2 and P at the follicular phase significantly decreased, and the secretive peak value at the luteal phase did not come into being.
CONCLUSIONS
Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi. One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2 and P.
目的
探讨卵巢激素变化对特定亚型经前期综合征（PMS）发病机制的影响，揭示肝郁气滞的部分微观机制。
方法
采用放射免疫法测定月经周期不同阶段血清雌二醇（E2）和孕酮（P）水平。
结果
肝郁气滞型PMS组中，E2和P在卵泡期的分泌峰值显著降低，黄体期未出现分泌峰值。
结论
卵泡期E2和P分泌峰值低以及黄体期无分泌峰值是肝郁气滞型PMS的微观机制之一。特定亚型PMS的病理生理机制之一可能是E2和P持续处于低水平。
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