Sundström I, Bäckström T
Department of Obstetrics and Gynecology, University Hospital of Umeå, Sweden.
Biol Psychiatry. 1998 Oct 15;44(8):755-64. doi: 10.1016/s0006-3223(98)00012-2.
Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients.
Saccadic eye movements were examined in 21 women with and 21 women without PMS on two occasions in the midfollicular and late luteal phase, respectively. On each occasion, plasma levels for estradiol, progesterone, and neuroactive progesterone metabolites were determined.
PMS patients had decreased saccadic eye velocity (SEV) compared to control subjects. This finding was most evident in the luteal phase, whereas the difference between groups approached significance in the follicular phase. Saccade accuracy and saccade latency were not different between the two groups. Control subjects increased their SEV in the luteal phase compared to the follicular phase, whereas PMS patients did not. PMS patients rated themselves more sedated than control subjects on the testing days in both phases of the menstrual cycle. Plasma levels of gonadal hormones and neuroactive steroids did not differ between the study groups.
The findings of a decreased SEV in PMS patients could be due to poor sleep and consequently increased sedation, but might also indicate that gamma-aminobutyric acidergic inhibition is different in patients with premenstrual syndrome.
先前对经前综合征（PMS）患者的神经生理学研究显示，在月经周期的两个阶段睡眠脑电图均有改变。我们报告一项评估PMS患者眼球快速运动的研究。
分别在卵泡中期和黄体晚期对21名患有PMS的女性和21名未患PMS的女性进行两次眼球快速运动检查。每次检查时，测定雌二醇、孕酮和具有神经活性的孕酮代谢产物的血浆水平。
与对照组相比，PMS患者的眼球快速运动速度（SEV）降低。这一发现在黄体期最为明显，而在卵泡期两组之间的差异接近显著。两组之间的扫视准确性和扫视潜伏期没有差异。与卵泡期相比，对照组在黄体期的SEV增加，而PMS患者则没有。在月经周期的两个阶段的测试日，PMS患者对自己的镇静程度评价高于对照组。研究组之间的性腺激素和神经活性类固醇的血浆水平没有差异。
PMS患者SEV降低的结果可能是由于睡眠不佳以及由此导致的镇静作用增强，但也可能表明经前综合征患者的γ-氨基丁酸能抑制作用有所不同。
