Iakovleva I N, Shishkov R V, Poliakov V G, Pankova P A
Vopr Onkol. 2008;54(3):315-20.
The paper deals with a comparison of clinico-morphological patterns of sporadic thyroid cancer and that in pediatric patients exposed to radiation during the Chernobyl disaster. The latter are highly prone to both local and regional metastatic spread to the lymph nodes (intrathyroid distribution--61%; extension through capsule--42%, and metastases to the neck lymph nodes--66%). However, these data do not differ significantly from those for intact areas. Yet, cancer occurs in exposed cohorts at an earlier stage: its incidence at age 4-6 is 2-3.5 higher and that of relapse such as presentation of latent metastases to the lymph nodes and tumor foci development in residual tumor tissue is 1.6 times the average. Also, morphological patterns have changed: typical papillary cancer incidence has dropped by half while the diffuse follicular variety has grown 1.8-fold.
本文探讨了散发性甲状腺癌与切尔诺贝利灾难期间遭受辐射的儿科患者的临床形态学模式比较。后者极易发生局部和区域淋巴结转移（甲状腺内分布——61%；穿透包膜——42%，颈部淋巴结转移——66%）。然而，这些数据与未受影响区域的数据无显著差异。不过，受辐射人群的癌症发病更早：4至6岁时的发病率高出2至3.5倍，而复发率，如淋巴结隐匿性转移和残留肿瘤组织中肿瘤病灶发展的复发率是平均水平的1.6倍。此外，形态学模式也发生了变化：典型乳头状癌的发病率下降了一半，而弥漫性滤泡型则增长了1.8倍。
