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[牛磺酸和硫辛酸对实验性糖尿病大鼠碳水化合物代谢及抗氧化系统的影响]

[Effect of taurine and thioctacide on carbohydrate metabolism and the antioxydant system in rats with experimental diabetes].

作者信息

Gavrovskaia L K, Ryzhova O V, Safonova A F, Aleksandrova I Ia, Sapronov N S

出版信息

Eksp Klin Farmakol. 2008 May-Jun;71(3):34-5.

PMID:18652254
Abstract

Peroral administration of taurine and thioctacide in rats with alloxan-induced diabetes (i) decreased the levels of glucose, fructosamine and MDA, (ii) increased the levels of glycogen, insulin, and C-peptide in the liver, and (iii) increased the levels of enzymes of the antioxidant system of catalase and paraoxonase as compared to the control group of animals. These effects show that taurine and thioctacide possess hypoglycemic and antioxidant properties.

摘要

给四氧嘧啶诱导的糖尿病大鼠经口给予牛磺酸和硫辛酸,(i)降低了葡萄糖、果糖胺和丙二醛的水平,(ii)增加了肝脏中糖原、胰岛素和C肽的水平,并且(iii)与对照组动物相比,增加了过氧化氢酶和对氧磷酶抗氧化系统的酶水平。这些作用表明牛磺酸和硫辛酸具有降血糖和抗氧化特性。

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