[Effect of adrenaline on the cytochrome P4502E1 content in microsomes and lysosomal fractions induced by isoniazid in rats].

Cytochrome P4502E1 levels in microsomal and lysosomal liver fractions was studied in Wistar rats treated with epinephrine (5.5 x 10(-6) mole/g, i.p., 1 h before test) on the background of isoniazid administration (daily dose 250 mg/kg, i.p., for 3 days). Epinephrine administration resulted in increased cytochrome P4502E1 level in the vacuole/lysosome apparatus of rat liver. On the background of isoniazid administration, cytochrome P4502E1 level and p-nitrophenol-hydroxylase activity in both low- and high-density lysosomes were decreased. Epinephrine administration under these conditions increased the cytochrome P-4502E1 level in lysosomes due to autophagy.