Tangurek B, Ketenci B, Ozay B, Ozer N, Yilmaz H, Sayar N, Ciloglu F, Gorur A, Bolca O
Cardiology Department, Siyami Ersek Cardiovascular and Thoracic Surgery Centre, Training and Research Hospital, Istanbul, Turkey.
J Int Med Res. 2008 Jul-Aug;36(4):714-20. doi: 10.1177/147323000803600413.
The relationship between angiotensin-converting enzyme (ACE) gene polymorphism and type I aortic dissection was examined in 205 unrelated hypertensives. A total of 94 patients underwent emergency repair due to type I aortic dissection, confirmed by computed tomography, and the remaining 111 were controls. Polymerase chain reaction was used to confirm that ACE gene polymorphism was due to insertion (I) or deletion (D) of a 287 base pair (bp) DNA sequence within intron 16. The genotype distribution and allele frequency of ACE I/D polymorphism between patients and controls were not statistically significant. When the frequency of at least one D allele carrier (DD or ID genotype) was compared with the II homozygous genotype, there was also no significant difference between the study groups. The findings revealed no association between ACE I/D polymorphism and aortic dissection. We conclude that I/D mutation of the ACE gene does not seem to be a risk factor for aortic dissection.
在205名无亲属关系的高血压患者中，研究了血管紧张素转换酶（ACE）基因多态性与I型主动脉夹层之间的关系。共有94例患者因I型主动脉夹层接受了急诊修复，经计算机断层扫描确诊，其余111例为对照。采用聚合酶链反应来确认ACE基因多态性是由于第16内含子内287个碱基对（bp）DNA序列的插入（I）或缺失（D）所致。患者与对照之间ACE I/D多态性的基因型分布和等位基因频率无统计学意义。当将至少一个D等位基因携带者（DD或ID基因型）的频率与II纯合基因型进行比较时，研究组之间也无显著差异。研究结果显示ACE I/D多态性与主动脉夹层之间无关联。我们得出结论，ACE基因的I/D突变似乎不是主动脉夹层的危险因素。
