在鼠类HIV-1脑炎中，血源性巨噬细胞穿过血脑屏障进入脑组织。
Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.
作者信息
Liu Yutong, Uberti Mariano G, Dou Huanyu, Banerjee Rebecca, Grotepas Cassi B, Stone David K, Rabinow Barrett E, Gendelman Howard E, Boska Michael D
机构信息
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-5880, United States.
出版信息
J Neuroimmunol. 2008 Aug 30;200(1-2):41-52. doi: 10.1016/j.jneuroim.2008.06.009. Epub 2008 Jul 24.
Abstract
Blood-borne macrophage ingress into brain in HIV-1 associated neurocognitive disorders governs the tempo of disease. We used superparamagnetic iron-oxide particles loaded into murine bone marrow-derived macrophages (BMM) injected intravenously into HIV-1 encephalitis mice to quantitatively assess BMM entry into diseased brain regions. Magnetic resonance imaging tests were validated by histological coregistration and enhanced image processing. The demonstration of robust BMM migration into areas of focal encephalitis provide 'proof of concept' for the use of MRI to monitor macrophage ingress into brain.
摘要
在与HIV-1相关的神经认知障碍中，血源性巨噬细胞进入大脑决定了疾病的发展进程。我们将超顺磁性氧化铁颗粒加载到小鼠骨髓来源的巨噬细胞（BMM）中，然后静脉注射到患有HIV-1脑炎的小鼠体内，以定量评估BMM进入患病脑区的情况。磁共振成像测试通过组织学配准和增强图像处理得到验证。强有力的BMM迁移至局灶性脑炎区域的证明为使用MRI监测巨噬细胞进入大脑提供了“概念验证”。
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