Jacobsen Mette D, Bougnoux Marie-Elisabeth, d'Enfert Christophe, Odds Frank C
Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Res Microbiol. 2008 Jul-Aug;159(6):436-40. doi: 10.1016/j.resmic.2008.05.003. Epub 2008 Jun 17.
Multilocus sequencing strain types of a panel of 43 Candida albicans isolates from animals, including mammals and avian species, were compared with strain types for human isolates. The clade distribution of the animal isolates was significantly different from that of the human isolates, in both a comparison involving a total of 1580 isolates from multiple geographical sources and a comparison restricted to 675 human isolates from the same geographical regions as the animal isolates. A nearest-neighbour analysis involving the 43 animal isolates and 67 human isolates, randomly selected to give a proportionate distribution of geographical sources, showed a strong statistical trend towards genetic selection of different C. albicans strain types adapted to non-human animal hosts, but without complete genetic separation.
对一组来自包括哺乳动物和鸟类在内的动物的43株白色念珠菌分离株的多位点测序菌株类型，与人类分离株的菌株类型进行了比较。在一项涉及来自多个地理来源的总共1580株分离株的比较中，以及在一项仅限于与动物分离株来自相同地理区域的675株人类分离株的比较中，动物分离株的进化枝分布与人类分离株的进化枝分布显著不同。一项涉及43株动物分离株和67株人类分离株的最近邻分析（随机选择这些分离株以实现地理来源的比例分布）显示，存在一种强烈的统计趋势，即倾向于对适应非人类动物宿主的不同白色念珠菌菌株类型进行遗传选择，但没有完全的遗传分离。
