一系列唐氏综合征婴幼儿白内障手术后的结果
Postcataract surgery outcome in a series of infants and children with Down syndrome.
作者信息
Gardiner C, Lanigan B, O'Keefe M
机构信息
The Children's University Hospital, Temple Street, Dublin 1, Ireland.
出版信息
Br J Ophthalmol. 2008 Aug;92(8):1112-6. doi: 10.1136/bjo.2007.134619.
AIMS
To report the visual and refractive outcome and complications in children with Down syndrome undergoing cataract extraction.
METHODS
The case notes of 18 infants and children with lens opacities and Down syndrome who underwent cataract extraction between January 1981 and August 2006 were reviewed.
RESULTS
Over the 25-year study period, 7% (33 eyes) of paediatric eyes undergoing cataract extraction had Down syndrome. The average follow-up time was 11.2 (SD 7.5) years with a range of 2.5 months to 25 years. 25 were congenital, and eight were developmental lens opacities. 40% of patients attained a postoperative BCVA between 6/9 and 6/18. There was a large myopic shift of -7.96 (4.7) D for aphakes and -8.06 (7.4) D for pseudophakes with an average increase in axial length of 3.58 (3.14) mm. There was a 30% incidence of posterior capsular opacification (PCO) overall, 38% in eyes without a primary posterior capsulotomy. Five eyes developed aphakic glaucoma, one eventually necessitating an enucleation. Two patients had retinal detachments on follow-up.
CONCLUSION
Cataract extraction in our population of children with Down syndrome is a safe and effective procedure with a very encouraging visual outcome.
目的
报告唐氏综合征患儿白内障摘除术后的视力、屈光结果及并发症。
方法
回顾1981年1月至2006年8月期间18例患有晶状体混浊的唐氏综合征婴幼儿及儿童白内障摘除手术的病历。
结果
在25年的研究期间，接受白内障摘除手术的儿童眼中，7%（33只眼）患有唐氏综合征。平均随访时间为11.2（标准差7.5）年，范围为2.5个月至25年。25例为先天性白内障，8例为发育性晶状体混浊。40%的患者术后最佳矫正视力达到6/9至6/18。无晶状体眼近视度数大幅偏移-7.96（4.7）D，人工晶状体眼近视度数大幅偏移-8.06（7.4）D，眼轴平均增加3.58（3.14）mm。后囊膜混浊（PCO）总发生率为30%，未行一期后囊切开术的眼中发生率为38%。5只眼发生无晶状体性青光眼，1只最终需要眼球摘除。2例患者随访期间发生视网膜脱离。
结论
对我们研究中的唐氏综合征患儿进行白内障摘除术是一种安全有效的手术，视力结果非常令人鼓舞。
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