Fillion C, Chaouat G, Reinaud P, Charpigny J C, Martal J
U 262 INSERM, Maternité de Baudelocque, Paris, France.
J Reprod Immunol. 1991 Apr;19(3):237-49. doi: 10.1016/0165-0378(91)90038-r.
The immunosuppressive properties of ovine trophoblastin protein (oTP) isoforms purified to homogeneity by DEAE HPLC have been studied within and across species barriers by in vitro assays. It has been demonstrated that not only the classical oTP 1, but in fact all 5 isoforms, are immunosuppressive in a PHA-induced proliferation assay, whilst being ineffective on IL-2 dependent CTL-L2 cell replication. The significance of these findings is discussed.
通过DEAE高效液相色谱法纯化至同质的绵羊滋养层蛋白（oTP）亚型的免疫抑制特性已通过体外试验在种内和种间屏障进行了研究。结果表明，不仅经典的oTP 1，实际上所有5种亚型在PHA诱导的增殖试验中都具有免疫抑制作用，而对IL-2依赖的CTL-L2细胞复制无效。讨论了这些发现的意义。
