Koh Eun-Ha, Kim Sunjoo, Lee Nam Yong
Department of Laboratory Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
Jpn J Infect Dis. 2008 Jul;61(4):261-3.
With the increasing resistance of group A streptococci (GAS) to macrolides in some countries including Korea, throat cultures were taken from healthy elementary school children to isolate GAS in 2004. Antibiotic susceptibility, macrolide-resistant phenotypes and genotypes as well as emm genotyping were studied and compared with previous data in 2002. In the present study, resistance rates to erythromycin and clindamycin in 2004 decreased to 9.8 and 8.8%, respectively, compared with 51.0 and 33.7%, respectively, in 2002. While emm44/61 increased from 0 to 29.3%, emm12 decreased from 34.4 to 6.4% during the 2002 - 2004 period. All emm44/61 strains were susceptible to erythromycin, while 81.0% of emm12 strains were resistant to erythromycin. The dramatic decrease of erythromycin resistance during this short period might be related to a change in the distribution of emm types in the community.
在包括韩国在内的一些国家，A 组链球菌（GAS）对大环内酯类药物的耐药性不断增加，因此在 2004 年对健康小学生进行了咽拭子培养以分离 GAS。研究了抗生素敏感性、大环内酯类耐药表型和基因型以及 emm 基因分型，并与 2002 年的先前数据进行了比较。在本研究中，2004 年对红霉素和克林霉素的耐药率分别降至 9.8%和 8.8%，而 2002 年分别为 51.0%和 33.7%。在 2002 - 2004 年期间，emm44/61 从 0 增加到 29.3%，而 emm12 从 34.4%降至 6.4%。所有 emm44/61 菌株对红霉素敏感，而 81.0%的 emm12 菌株对红霉素耐药。在这一短时期内红霉素耐药性的显著下降可能与社区中 emm 型分布的变化有关。
