Nakayama Mitsuyuki, Asari Yasuhiro
Department of Vascular Surgery, Kanoiwa Hospital, Yamanashi, Japan.
Circ J. 2008 Aug;72(8):1385-7. doi: 10.1253/circj.72.1385.
Patients demonstrating critical limb ischemia with a long-distance occlusion of the major arteries are sometimes poor candidates for bypass surgery, because tandem occlusion complicates distal anastomoses and poor run-off causes early occlusion of bypass grafts. In order to resolve these problems, angiogenesis therapy was attempted by subcutaneous injection of granulocyte colony-stimulating factor either before or after peripheral bypass surgery in 2 cases.
表现为主要动脉长段闭塞的严重肢体缺血患者有时并非旁路手术的理想候选者，因为串联闭塞会使远端吻合复杂化，而血流灌注不佳会导致旁路移植物早期闭塞。为了解决这些问题，对2例患者在周围旁路手术之前或之后通过皮下注射粒细胞集落刺激因子尝试进行血管生成治疗。
